Christopher Reeve has died, his publicist has said.
The 52-year-old fell into a coma on Saturday after suffering a cardiac arrest at his New York home.
Reeve had been paralysed from the neck down in a near-fatal horse-riding accident nine years ago.
The former actor spent most of his time since in a wheelchair and became an advocate for spinal cord research.
I just watched Superman 3 the other day. I love those movies… even now. I always saw Christopher Reeve’s as this tough guy that could save the world. When I would see him in that wheel chair it was almost too hard to believe that it was him. He had such a will to live. Vowing to the day he was gone that he’d walk again someday. Hopefully somebody else will stand up to help Michael J Fox in the fight for stem cell research.